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Title   악성종양 환자에서 Cisplatin 병용 화학요법시 Ondansetron 의 오심 및 구토 억제 효과 ( Effet of Ondansetron in the Prevention of Nauses and Vomiting Associated with Cisplatin Chemothrapy in Cancer Patients )
Publicationinfo   1993 Jan; 025(02): 299-307.
Key_word   Ondansetron, Nausea, Cisplatin
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Abstract   Ondansetron is a new, highly selective S-HT, antagonist which has been shown to be highly effective in the prevention of nausea and vomiting induced by cisplatin and non-cisplatin chemotherapy. We evaluated the efficacy and safety of ondansetron in preventing nausea and vomiting induced by cisplatin containing chemotherapy regimen#. The patients received 8 mg of ondansetron in a slow intravenous infusion 30 minutes before the administration of cisplatin, which has followed by a continous infusion of ondansetron for 24 hours at the rate of 1 mg/ hour. At the end of the first 24 hours period, ondanseteron was administered as an oral dosage of 8 mg every 8 hours for the next 5 days. Twenty patients(14 men and 6 women) enrolled in this study whose mean age was 46 years old. The patients received 40 to l20 mg/m(2) of cisplatin (mean 75 mg/m(2)). Nausea was controlled in 60% of the patients(none: 35%, mild: 25%) and emesis(vomiting and retching) was controlled in 60% of the patients(complete: 35%, major: 25%) on Day 1. On Day 2 to 6, nausea was controlled in 45% of the patients(none: 25%, mild: 20%) and emesis was con- trolled in 55%(complete: 25%, major: 30%) of the patients. The side effects of ondansetron were observed in 10 patients with mild headache(25%), chest discomfort(20%), and mild fever(5%). No extrapyramidal symptom was noted. These results showed that ondansetron is an effective and safe agent for controlling the nausea and vomiting induced by cisplatin treatment.
저 자   신상원(Sang Won Shin),최경묵(Kyung Mook Choi),연종은(Jong Eun Yeon),박상면(Sang Myun Park),최철원(Chul Won Choi),김준석(Jun Suk Kim)